九州大学 大学院 システム生命科学府

Division of Medical Molecular Cell Biology

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Division of Medical Molecular Cell Biology

In the post-genome era, the most important issue in human biology is the diversity at different levels of human nature such as “cell to cell”, “tissue to tissue”, “male and female” and “population to population”. The difference in disease susceptibility among individuals has been one of the critical issues in medical science. The mission of our division is to nurture researchers (and advanced technical experts) who can effectively address the issues in modern human biology. We expect young researchers not only to pursue the experiments intensively, but also to devise adequate experiments by fully utilizing the enormous ” omics ” data available.

In addition, current research in human biology must fully address bioethical issues based on the integration of perspectives from medical research and medical care, and the concerns of society and individuals. We provide comprehensive educational opportunities to students for the diverse field of medical genome sciences including molecular medicine, molecular biology, genetics and population genetics, structural biology, bioinformatics, and bioethics. We also provide the students the opportunities of joining in cutting-edge research projects, such as 1) the analysis of human variation viewed from genomic diversity; 2) the analysis of homeostatic mechanisms based on genome information; 3) the structural and functional analysis of proteins and their application for medicine; 4) the genetic analysis of multifactorial disorders and intractable disorders; and 5) the development of new methods of data analysis to expand the medical knowledge.

>>> Molecular Cell Biology >>> Biology of Sex Differentiation >>> Computational Biology >>> Human Molecular Genetics >>> Structural Life Science >>> Integrated Omics >>> Cellular Memory >>> Metabolomics

■Molecular Cell Biology

kondou

Professor Hisao Kondo

Department of Molecular Biology, Faculty of Medical Sciences (Hospital campus
E-mail:
URL:http://www.cellbiology.med.kyushu-u.ac.jp/saiboukougaku/Kondo-Lab.html

The Golgi apparatus is a center of membrane traffic and its biogenesis is one of the most important issues in cell biology. The Golgi apparatus undergoes the most dramatic transformation during the cell cycle. Once the eukaryotic cell enters the mitotic phase, it is fragmented and dispersed throughout the cytoplasm at mitosis. After cell division, the Golgi apparatus is rebuilt in each daughter cell from fragments. For its reassembly, at least two ATPases are necessary; N-ethylmaleimide-sensitive factor (NSF) and p97. Although the NSF pathway has been well characterized, the mechanism of the p97 pathway still remains unclear. We previously discovered two distinct p97ATPase-mediated membrane fusion machineries, the p97/p47 and p97/p37 pathways. In order to clarify the biogenesis of the ER and Golgi, we have been investigating the molecular mechanism of these two p97 membrane fusion pathways.

 

■Biology of Sex Differentiation

morohashi

Professor Kenichiro Morohashi

Department of Molecular Biology, Faculty of Medical Sciences (Hospital campus
E-mail:
Most organisms have developed the two sexes, male and female, and thus established sexual reproduction. The most prominent difference between the two sexes can be seen in the gonads, the testis in the male and the ovaries in the female. The gonads produce not only germ cells (sperm in the testis and eggs in the ovaries) but sex steroids (androgen in the male and estrogen in the female), which subsequently induce sex differences in throughout the whole body. Accordingly, sex differentiation of the gonads is the key event for establishment of sex differentiation of individuals. The early stages of the developing gonads are still sexually indifferent and thereafter sexually differentiated into the testis or ovary due to a combination of sex chromosomes. The aim of our study is to understand the mechanisms underlying sex differentiation of the gonads and whole body.

■Computational Biology

suyama_phot

Professor Mikita Suyama

Division of Bioinformatics, Medical Institute of Bioregulation Division of Bioinformatics, Medical Institute of Bioregulation
E-mail:
URL:http://www.bioreg.kyushu-u.ac.jp/labo/bioinfo/

The main focus of our group is in understanding the information written in genomes by computational biological approaches. More specifically, we are mainly analyzing genomic sequences and epigenomic data to get much insight into gene regulation. The current research topics include (1) comparative genome analyses and the analyses of the data from next generation sequencing platforms to understand the mechanisms of gene regulation, (2) molecular evolutionary analyses of gene duplications and genome rearrangements, and (3) gene expression by using data from RNA-seq and microarray.

■System Cohort

yamanishi1

Associate Professor Yoshihiro Yamanishi

Division of System Chort, Medical Institute of Bioregulation (Hospital campus
E-mail:
URL:http://www.bioreg.kyushu-u.ac.jp/labo/systemcohort/
Our research objective is to develop information technologies to analyze bio-molecules (e.g., genes, proteins, compounds, drugs) in biomedical science. In particular, we develop novel statistical methods to predict various molecular interaction networks (e.g., gene functional network, protein-protein interactions, metabolic pathways) from heterogeneous omics data such as genome, transcriptome, proteome, metabolome, and phenome. We also work on medical and pharmaceutical applications such as prediction of drug targets in the framework of chemogenomics and pharmacogenomics, prediction of new drug indications for drug repositioning, and data-driven stratification of patients for precision medicine (personalized medicine).

 

■Human Molecular Genetics

hi-shibata

Associate Professor Hiroki Shibata

Division of Bioinformatics, Medical Institute of Bioregulation (Hospital campus
E-mail: mikita (at) bioreg.kyushu-u.ac.jp
URL:http://www.gen.kyushu-u.ac.jp/~byouin/
What makes us human? The genetic and evolutionary bases of the highly sophisticated function of the human brain, such as cognition and intelligence are largely unknown. Psychiatric diseases are the natural model of dysfunction of the human brain. Therefore, genes that are susceptible to psychiatric diseases are strong candidates for genes involved in the evolutionary process of human brain function. To clarify the mode and the target of natural selection that has shaped human brain function, we are working on the following projects:

  1. comparative genomics of the glutamate receptor genes among primates.
  2. population genetics of the genes associated with major psychiatric diseases such as schizophrenia.

and

  1. genetic analysis of hereditary neurological diseases.

■Structural Life Science

kouda

Professor Daisuke Kohda

Division of Structural Biology, Medical Institute of Bioregulation (Hospital campus
E-mail:
URL:http://www.bioreg.kyushu-u.ac.jp/vsb/index.html
Structural biology is a powerful approach to understanding the functions of biomacromolecules on the basis of their structures at atomic resolutions. We focus on protein-protein and protein-peptide interactions under the concept of “structure at work”. We are particularly interested in molecular recognitions with non-strict specificity and weak affinity. We always carefully select targets, of which the structure will have an impact on their biological aspects. Our current targets include the mitochondrial protein import system, the N-glycosylation system, and the NADPH oxidase system. We use X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryoelectron microscopy. Although structure determination forms the core of our approach, it is essential that we also understand the tight coupling of structure determination and biology.
shimada2

Associate Professor Atsushi Shimada

Division of Structural Biology, Medical Institute of Bioregulation (Hospital campus
E-mail:
URL:http://www.bioreg.kyushu-u.ac.jp/vsb/index.html
Endocytosis and cell migration are dynamic processes of eukaryotic cells accompanied by membrane and/or actin cytoskeletal remodeling. These processes are regulated by cellular signaling pathways, which link extracellular signals to corresponding morphological changes of the cell. A number of proteins are involved in these pathways, including those with membrane and/or cytoskeletal remodeling activities. However, the detailed functions of these proteins at atomic resolutions are still not fully understood. To reveal the mechanisms underlying the functions exerted by these proteins, we use mainly X-ray crystallography and various biochemical techniques, such as isothermal titration calorimetry, for structural and functional analyses. We also perform cell biological analyses to test hypotheses derived from structural and functional analyses in collaboration with other groups.

■統合オミクス

Kubota

Integrated Omics

Medical Institute of Bioregulation (Hospital campus
E-mail:
URL:http://www.bioreg.kyushu-u.ac.jp/labo/omics/

 
 

Uda

Associate Professor Shinsuke Uda

Medical Institute of Bioregulation (Hospital campus
E-mail:
URL:http://www.bioreg.kyushu-u.ac.jp/labo/omics/
Graduate School of SystemsLife Sciences Kyushu University

Grad. Sch. Sys. Life Sci.
Kyushu University
744 Motooka
Nishi-ku 819-0395
Japan

Kyushu University
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