九州大学 大学院 システム生命科学府

Division of Life Engineering

Contents

Division of Life Engineering

Future research will continue the development of fundamental science, from application to biodiversity such as deciphered expectations for tailor-made medicine based on the genome and the beginnings of regenerative medicine. The content for the Division of Life Engineering was established with the following statement as a starting point, “Engineering plays a role in the development and application of science, and in the improvement of people’s lives.” There are in fact many fields where industrialization based on the development of life sciences can be attempted. Our aim is to train talented researchers with backgrounds in agriculture and engineering so as to be able to play an active role in the following fields in the biotechnology course.

a. Promotion of biotechnology, for instance, as involved in the production of medicines and functional foods through the use of discovered and deciphered genomes in the performance analysis, effective uses, and production of various biological macromolecules.

b. Promotion of biotechnology, where the role of the biomedical engineer is to learn the biological, chemical, and physical aspects of organization and internal organs of the living body, as well as to develop various techniques and materials targeting internal reproductive organs; as such, biomedical engineering is closely related to the important fields of regenerative medicine, medical history, operation techniques, mechanical organs, and the development of implants for patients with challenging illnesses, with the aim of contributing to saving patients’ lives and improving their quality of life.

c. The field of macromolecular biology focuses on bio-compatibility, biodegradability,and biological absorption of indispensable materials in regenerative medicine, with the aim of limiting the impact on the environment. Biological macromolecule research is likely to have a large impact on the market, with its focus on high performance materials for regenerative medicine, but also raw materials that harmonize with the environment. This field of study promotes the training of biomaterial engineers with a deep understanding of biological macromolecules, various bioceramics, metallic materials for the living body, the development of composite materials, and materials that are compatible with the application of nanotechnology.

d. We aim to promote the development of the up-to-date bioinstrumentation techniques of nano-micro diagnosis that apply to biotechnology imaging and the microelectromechanical system.

The following curriculums are offered according to the goals of the aforementioned human resources development. We believe our students should be able to acquire fundamental knowledge regarding living organisms, cells, and genomes, and to stay in touch with the rapid changes and developments in this field. The key is for students to learn to learn, or to remain flexible enough to update their knowledge autonomously Additionally, research subjects that are typically regarded as applications may have direct effects on students’ career paths. Moreover, it has become a worldwide trend to obtain patents for any invention, and so it is crucial that research findings are patented. Accordingly, we provide lectures on patent strategy and the start-up of a bio venture business.

■Life Process Engineering

kamihira

Professor Masamichi Kamihira

Department of Chemical Engineering, Faculty of Engineering (Ito campus

E-mail:
URL:http://www.chem-eng.kyushu-u.ac.jp/lab3/Eng_ver.html

Biological systems have generated ingeniousness by evolving their processes from an individual level to combined levels (from gene to cell, and tissue/organ to organism). The aim of our laboratory’s research is the development of new biotechnology by analyzing the complexity of biological systems and life phenomena, and by attempting to reconstruct these artificially. We are particularly interested in research and design with respect to:

  1. gene transfer techniques;
  2. artificial organs;
  3. transgenic animals;
  4. stem cell technology;
  5. molecular biology of functional cells;

and 6) the production of useful substances using cultured cells.

mizumoto

Associate Professor Hiroshi Mizumoto

Department of Chemical Engineering, Faculty of Engineering (Ito campus
E-mail:
URL:http://hyoka.ofc.kyushu-u.ac.jp/search/details/K001447/e

Regenerative medicine and hybrid artificial organs have much
attention as a possible method for treating patients suffering from
severe organ failure. To put these technologies into practical use, it
is necessary to establish a process, which enable the provision of an
adequate number of functional cells for clinical applications. In this
situation, we focus on pluripotent stem cells (ES cells and iPS cells). We
try to establish a cultivation system for self-renewal of stem cells, or a
cultivation system for differentiation of stem cells into various types of
functional matured cells in a large scale. In parallel, we try to fabricate a
natural-like functional tissue construct from cultured cells. Also, we try
to develop some artificial organ devices with these engineered tissue
constructs and to evaluate these devices in animal experiments.

■Biotechnologies for Therapy, Diagnosis and Drug Discovery

katayama

Professor Yoshiki Katayama

Department of Applied Chemistry, Faculty of Engineering (Ito campus
E-mail:
URL:http://www.chem.kyushu-u.ac.jp/~katayama/

Our laboratory specializes in nano-biomaterials for cell-specific therapy, diagnosis and drug discovery, which includes new concepts of DDS and gene delivery systems, bio-imaging probes, and high throughput assay systems. We have developed new cell-specific drug and gene delivery systems responding to intracellular protein kinase or protease, imaging probes for protein kinase for detecting cancer activity, various high throughput assay systems of protein kinases by using peptide array, and gold nano-particle or fluorescence molecules. In our studies, we aim to create new concepts for the post-genomic era, and to apply the research results to life sciences, medicine, welfare and education.

kishimura

Associate Professor Akihiro Kishimura

Center for Molecular Systems Department of Applied Chemistry, Faculty of Engineering (Ito campus
E-mail:
URL:http://www.chem.kyushu-u.ac.jp/~katayama/

There have been many intractable diseases still left. To overcome this situation, new technology is required to clarify the reason why it is difficult to treat the intractable diseases by conventional pharmaceutical methods and current drug delivery system, particularly nano-medicine. In our group, functional nano-devices that can be used for drug delivery vehicles have been developed to obtain structural information of diseased parts at the nanoscopic level as well as some insights of their physicochemical properties. By utilizing our original techniques, properties of polymer nanoarchitectures, such as sizes, morphologies, softness, surface properties, stability and so on, have been tuned to clarify the “nano-pathophysiological properties” of target tissues. Also, nanopathophysiology is considered to contain the field of soft matter sciences, to describe extremely condensed environments found in the living things, for example, cytoplasm and body fluids, and dynamic environments mainly caused by the flow or circulation system in the body. We have carefully dealt with these issues to design nano-medicine of the next generation, and finally to establish the approach of “material physiology”. Novel therapeutics with higher efficacy must be achieved on the basis of the knowledge of nano-pathophysiology.

Associate Professor Takeshi Mori

Department of Applied Chemistry, Faculty of Engineering (Ito campus
E-mail:
URL:http://www.chem.kyushu-u.ac.jp/~katayama/

Cellular lipid bilayers are critical platforms for the myriad of functions performed by membrane proteins. These proteins perform together to correctly respond to outer stimuli. Thus, the cellular responses can be modified by artificial expression of membrane proteins on cell surface by transfection. This concept is called “cell surface engineering”, which has been gathering a lot of attentions recently. Our group approaches this cell surface engineering based on the chemical modification of the cell surface instead of the conventional transfection. As a basement molecule for modification of the cell surface, we have been developed polymeric anchors and peptide-based anchors. Utilizing these anchoring molecules, we modified the cell surface with artificial receptor and ligand molecules which endow homing and endocytotic characteristics to the cells, respectively, to aim effective cell therapy.

■Life Engineering and Physics

Professor Kazuhiro Hara

Department of Applied Quantum Physics and Nuclear Engineering, Faculty of Engineering (Ito campus
E-mail:
URL:

With small variation of environmental conditions, some substances making up the living body are known to show very large changes in their structures and functionalities, which is considered to be the origin of the distinctive properties of the biological systems. For making clear the characteristic mechanisms, we have been investigating the properties of hydrogels and hydrocolloids as the model substances of the living-system constituents, including the nano-scale structure investigations by utilizing the synchrotron-light and neutron scattering techniques. In addition to such basic investigations, we have been also developing the functional materials through the use of their discriminative properties serviceable for solving the environmental and resource depletion problems.

OKABE1

Associate Professor Hirotaka Okabe

Department of Applied Quantum Physics and Nuclear Engineering, Faculty of Engineering (Ito campus
E-mail:
URL:http://www.okabe.ap.kyushu-u.ac.jp/index-j.html

Although a living body is a complex system, we may be able to understand it by coarse graining and simplification. We are doing research from such a physical viewpoint. The present contents of research are the developments of the method of diagnosing a physiology state by measuring ultraweak light called the biophoton of reactive oxygen origin, and the soft matter actuator which is the candidate of an artificial muscle.

  1. Research of the artificial muscle using liquid crystal elastomer.
  2. Biophoton Emission from hand and root plant.

■Biofunctional Engineering

Professor Susumu Kudo

Department of Mechanical Engineering, Faculty of Engineering (Ito campus
E-mail:
URL:http://www.bfe.mech.kyushu-u.ac.jp/

We are elucidating the mechanisms by which the functions of cells and tissues adapt to mechanical environments on the basis of biomechanics. We are also trying to clarify the mechanism and micro- and nanoscopic biotransport. Macroscopic biotransport can be often be analyzed by using a differential equation to model physical phenomena. However, biotransport at much smaller scales (the micro-and nano-scales) is more difficult to model in physical detail. Clarification of the mechanisms of such micro- and nanoscale biotransport will be useful not only in improving our understanding of the mechanisms of disease and the maintenance of stable biological functions, but also for the development of clinical applications such as tissue engineering. The following are examples of the studies that have been performed.

  1. Effect of ambient temperature on finger skin blood flow
  2. Effect of shear stress on functions of endothelial cells
  3. Effect of shear stress on macromolecule permeability across endothelial cells
  4. Effect of flow load on hepatic function in co-culture of hepatocytes and endothelial cells
  5. Using a photochromic fluorescent protein to analyze membrane protein diffusion in endothelial cells under shear stress
  6. Visualization of intracellular diffusion in endothelial cell using photochromic fluorescent protein

■Advanced Medical Device

Professor Jumpei Arata

Department of Mechanical Engineering, Faculty of Engineering (Ito campus
E-mail:
URL:http://amd.mech.kyushu-u.ac.jp/jp/index.html

Our research aims at new medical applications based on
Robotic technology. Robotic technology includes many elements –
mechanism, sensor, control, system integration and etc.We study
about these elements to realize further effective medical applications.In recent years, medical robots were found to be effective,
namely, in Surgery and Rehabilitation [Trinh2012, Mehrholz2015,
Kwakkel2008].We further study about robotic technology to
extend the medical applications. One of our research topics is about
surgical robot. We recently presented a surgical manipulator
with 2 mm in diameter, realizing 4 degree-of-freedom at the tip.The manipulator was implemented by using largely deformable
elements that greatly contributed to the compact and sterilizable
structure [Arata2019]. Our hand rehabilitation robot is currently in
clinical trials under the collaboration with a pharmaceutical company,
a manufacturing company and a start-up company [Mukae2019].
The lab is collaborating with many external experts, including
medical doctors, therapists, engineers, public organizations and
companies to pursue new medical applications based on Robotic
Technology.

■Cellular Regulation Technology

katakura

Professor Yoshinori Katakura

Department of Bioscience and Biotechnology, Faculty of Agriculture Ito campus
E-mail:
URL:http://web.me.com/katakura/Site/TOP.html

Recently, oncogenes, oxidative stress, other forms of stress as well as telomere shortening have been shown to induce cellular senescence in normal human somatic cells. Cellular senescence is one of the triggers that cause age-related disorders in specific tissues and organs. We are now investigating the molecular basis for cellular senescence programs to understand age-related disorders, and are trying to develop anti-aging foods. Our research projects are as follows:1) the discovery of senescence-associated factors; 2) the elucidation of regulation mechanisms of telomerase; 3) the elucidation of signaling networks for senescence and aging; 4) the elucidation of roles of senesced cells in age-related diseases; and 5) the development of anti-aging foods.

■Biotechnology of Extremophiles

Professor Yosizumi Ishino

Department of Bioscience and Biotechnology, Faculty of Agriculture Ito campus
E-mail:
URL:

Under construction

Associate Professor Sonoko Ishino

Department of Bioscience and Biotechnology, Faculty of Agriculture Ito campus
E-mail:
URL:

Under construction

Graduate School of SystemsLife Sciences Kyushu University

Grad. Sch. Sys. Life Sci.
Kyushu University
744 Motooka
Nishi-ku 819-0395
Japan

Kyushu University
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